Method to prevent lethal bone marrow transplant complication discovered

Analysis of research article by ScienceDaily

Bone_marrow_WBC.JPGOriginal article: S. N. Furlan et al. Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention. Science Translational Medicine, 2015; 7 (315): 315ra191 DOI: 10.1126/scitranslmed.aad3231#

A Seattle Children’s Research Institute lab has discovered a genetic pathway that can be targeted with existing drugs to prevent graft-versus-host disease (GVHD), a common and deadly complication of bone marrow transplants. The results of their work were published in the journal Science Translational Medicine.

In patients with GVHD, newly transplanted T cells from the bone marrow graft attack the transplant recipient’s body. Over 10,000 people in the United States receive bone marrow transplants each year for leukemia, other non-malignant blood conditions and autoimmune diseases. About 50-70 percent of bone marrow transplant patients will acquire GVHD. Of those who develop the most severe form, up to half will die.

Read the full analysis via ScienceDaily

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