Ibrutinib superior to traditional chemotherapy in untreated chronic leukemia patients

Burger, J. et al. New England Journal of Medicine, 2015.

A multi-center, international, randomized, Phase III study of older untreated patients with chronic lymphocytic leukemia (CLL) demonstrated that ibrutinib, a kinase inhibitor, is significantly more effective than traditional chemotherapy with chlorambucil.

The study, which followed 269 patients, revealed a 24-month overall survival rate of 97.8 percent for patients taking ibrutinib versus 85.3 percent for those on chlorambucil. Minor adverse effects were reported.

Carry on reading commentary via ScienceDaily

View the full article via NEJM

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