Stomach cancer diagnostics: New insights on stage of tumor growth

Kazan Federal University. ScienceDaily. Published online 20 April 2016.
Image source: Wellcome Images // CC BY-NC-ND 4.0

Photomicrograph showing signet ring carcinoma of stomach.

Correlations have been found between the superoxide and nitric oxide generation rates, levels of active forms of MMP-2 and MMP-9 in tumor and adjoining tissues between each other and with the disease stages for gastric cancer patients.

Despite the reduction in incidence, stomach (gastric) cancer (SC) is still the second most frequent cause of cancer related death worldwide. According to the Russian national statistics, 38 318 new SC cases were diagnosed in 2011, and the most of them on the latest disease stages III-IV. In Ukraine in 2013 SC took the second and third places in the structure of men and women cancer related mortalities, correspondingly, though only the fourth (men) and the eights (woman) incidence places in the hierarchy of tumor diseases.

High levels of reactive oxygen (ROS) and nitrogen (RNS) species can lead to the destruction of extracellular matrix facilitating tumor progression. ROS can activate matrix metalloproteinases (MMP), damage DNA and RNA. Therefore, the levels of MMP, ROS and RNS can serve as additional prognostic markers and for the estimation of the effectiveness of tumor therapy.

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