Scientists discover drug combination slows lung cancer cell growth

B0006883 Lung cancer cells

Image shows lung cancer cell dividing. Source: Anne Weston, Wellcome images // CC BY-NC-ND 4.0

Scientists have shown that a drug combination slows cancer cell growth in a type of non small cell lung cancer when tested in the lab, offering potential for developing new treatments in the future.  Cancer Research UK | British Journal of Cancer

The drug combination delivers a double whammy to the way the KRAS gene makes cancer cells grow. KRAS is estimated to be mutated in 15 to 25 per cent of people with non-small cell lung adenocarcinomas – a disease affecting around 10,400 people in England each year.

The study looked at whether blocking the functions of two proteins called MEK and m-TOR would stop or slow down the growth of non-small cell lung adenocarcinoma cells in the laboratory.

Full reference: Broutin, S. et al.  Insights into significance of combined inhibition of MEK and m-TOR signalling output in KRAS mutant non-small-cell lung cancer. Br J Cancer 115: 549-552; doi:10.1038/bjc.2016.220

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s