NSAIDs and Endometrial Carcinoma Mortality and Recurrence

Brasky, T.M. et al. (2017) JNCI: Journal of National Cancer Institute. 109(3) djw251

B0010228 Diclofenac, anti-inflammatory and pain relief drug, LM
Image source: Maurice Mikkers – Wellcome Images // CC BY-NC-ND 4.0

Image shows cross polarised light micrograph of diclofenac.

Background: Recent data suggest that the use of nonsteroidal anti-inflammatory drugs (NSAIDs) may be associated with reductions in endometrial cancer risk, yet very few have examined whether their use is related to prognosis among endometrial cancer patients.


Conclusions: In this study, use of NSAIDs was associated with increased endometrial carcinoma–specific mortality, especially in patients with type I tumors. Barring a clear biologic mechanism by which NSAIDs would increase the risk of cause-specific mortality, cautious interpretation is warranted.

Read the full abstract here



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