Targeted Therapy in Thyroid Cancer

Valerio, L. et al. Clinical Oncology | Published online: 18 March 2017

Image shows photomicrograph (magnification X25, H & E stain) showing degenerating papillae in papillary carcinoma of the thyroid.

Thyroid cancer typically has a good outcome following standard treatments, which include surgery, radioactive iodine ablation for differentiated tumours and treatment with thyrotropine hormone-suppressive levothyroxine. Thyroid cancers that persist or recur following these therapies have a poorer prognosis. Cytotoxic chemotherapy or external beam radiotherapy has a low efficacy in these patients. ‘Target therapy’ with tyrosine kinase inhibitors (TKIs) represent an important therapeutic option for the treatment of advanced cases of radioiodine refractory (RAI-R) differentiated thyroid cancer (DTC), medullary thyroid cancer (MTC) and possibly for cases of poorly differentiated (PDTC) and anaplastic thyroid cancer (ATC).

Read the full abstract here

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