New way to target the growth of breast cancer cells

Researchers have found a new way of halting the growth of breast cancer cells. They hope that their discoveries can be further developed into a new way of treating breast cancer, and possibly other types of cancer. | Nature Communications | via ScienceDaily

An international team of researchers led from Karolinska Institutet and Science for Life Laboratory in Sweden have found a new way of halting the growth of breast cancer cells. In their study, which is published in Nature Communications, the researchers explore a new way to starve cancer cells from their molecular energy source.

In the study, the researchers confirmed that hormone-driven breast cancer cells use a newly discovered protein, NUDT5, to produce energy in the cell nucleus. This nuclear energy source provides energy for the expression of genes that drive cancer growth.

In the next stage of their research, they developed a molecule able to block NUDT5 activity and thus deprive the cancer cells of their means of nuclear energy production. They demonstrated that this new molecule can stop the growth of breast cancer cells in isolated laboratory experiments.

Full detail at ScienceDaily

Full reference: Page, B et al. | Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells | Nature Communications |  2018; 9 (1)

 

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