University of Edinburgh | June 2018 | Aspirin’s anti-cancer effects revealed
Researchers at the University of Edinburgh have discovered aspirin blocks a key process linked to tumour formation. Although aspirin is recognised for its ability to reduce an individual’s risk of developing colon cancer-if taken regularly- its tumour fighting properties have been little understood. The team looked at the impact of taking aspirin to fight bowel cancer; focusing on a structure found inside cells called the nucleolus. They tested aspirin tumour biopsies removed from patients with colon cancer, and cells grown in the lab. Their research discovered that aspirin blocks TIF-IA a key molecule essential to the functioning of the nucleolus (via University of Edinburgh).
Full press release from University of Edinburgh here
The full article is available to read from Nucleic Acids Research
Chen, J. et al |2018| Identification of a novel TIF-IA–NF-κB nucleolar stress response pathway| Nucleic Acids Research| gky455| https://doi.org/10.1093/nar/gky455
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