[Technology Appraisal Guidance] Lenalidomide plus dexamethasone for multiple myeloma after 1 treatment with bortezomib

NICE | June 2019| Lenalidomide plus dexamethasone for multiple myeloma after 1 treatment with bortezomib Technology appraisal guidance [TA586]

NICE has published Evidence-based recommendations on lenalidomide (Revlimid) plus dexamethasone for multiple myeloma after 1 treatment with bortezomib in adults.

This guidance looks at the use of lenalidomide for multiple myeloma as second-line treatment. For third- or further-line use, please see NICE’s technology guidance on lenalidomide for the treatment of multiple myeloma in people who have received at least 2 prior therapies.

Full details from NICE 

NHS prepares to fast-track ‘game changing’ cancer drugs that target genetic mutations

The NHS is preparing to fast-track the introduction of ‘game changing’ new cancer drugs that target tumours according to their genetic make-up rather than where they originate in the body | NHS England

The revolutionary treatments – known as ‘tumour agnostic’ drugs – can be used against a wide range of cancers and could offer hope to patients with rare forms of the disease that may previously have been untreatable.

The first of the new cancer drugs, which target genetic mutations that accelerate the growth of many types of tumours and have particular benefits for children, are set to come on to the market within months.

With such treatments, testing the tumour’s genes or other molecular features assists in deciding which treatments may be best for an individual with cancer, regardless of where the cancer is located or how it looks under the microscope. Molecular testing therefore becomes a first and essential element of treatment planning.

Around 850 patients a year could benefit from the frontrunners while many thousands a year are eventually expected to benefit from other tumour agnostic treatments on the horizon.

Full story at NHS England


Societal impact of treatment of early breast cancer

RAND Europe has the findings from a study on the societal impact of early breast cancer.  The findings are published in the following reports:

Innovative brain cancer treatment aid now available across England

Department of Health and Social Care | May 2019 | Innovative brain cancer treatment aid now available across England 

An innovative brain cancer treatment could be used to help up to 2000 people a year. Cancer treatment aid 5-ALA (known as the pink drink) is now available across the country and will transform treatment for patients.

5-ALA uses fluorescent dye and ultraviolet light to make cancerous cells glow under UV light. This allows surgeons to more accurately identify the affected areas of the brain.

The treatment aid will help to tackle some of the hardest to treat cases and make sure healthy cells are left untouched.

Around 2,000 patients a year could benefit, according to new figures released today (Source: Department of Health and Social Care).

Full story available from  Innovative brain cancer treatment aid now available across England

[NICE Technology appraisal guidance] Abemaciclib with fulvestrant for treating hormone receptor-positive, HER2-negative advanced breast cancer after endocrine therapy

NICE |  May 2019| Abemaciclib with fulvestrant for treating hormone receptor-positive, HER2-negative advanced breast cancer after endocrine therapy Technology appraisal guidance [TA579]

NICE have publsihed technology appraisal guidance: Evidence-based recommendations on abemaciclib (Verzenios) for hormone receptor-positive, human epidermal growth factor 2 (HER2)-negative locally advanced or metastatic breast cancer in adults who have had endocrine therapy.

Full details from NICE 

Annual NHS cancer checks top two million for the first time

For the first time last year, the NHS in England carried out more than two million checks on people who feared they might have cancer.

In 2018, patients underwent a record 2.2 million cancer checks following urgent referral by their GP, almost 6,000 a day or more than four every minute. That was an increase of almost a quarter of a million on the 1.9 million people who were seen in 2017.

Record numbers of people also received treatment for cancer, with 308,058 receiving a first treatment in 2018, almost 13,000 more than in 2017 and the first time the number has topped 300,000.

Cancer survival is at an all time high with new figures showing 10,000 more patients surviving for at least 12 months after diagnosis than five years earlier. However, the NHS Long Term Plan aims to increasing the proportion of cancers caught early from half to three quarters, an improvement that will save up to 55,000 more lives each year.

Full story at NHS England

Advances in Cancer Treatment

Parliamentary Office of Science and Technology | April 2019 | Advances in Cancer Treatment

The latest POSTnote from the Parliamentary Office of Science and Technology gives an overview of recent advances in cancer treatment, the potential benefits and risks, and considers the opportunities and challenges to using new technologies in the NHS.

Image source: researchbriefings.parliament.uk


  • New cancer treatment technologies have shown promising results in clinical trials, particularly for difficult-to-treat cancers.
  • Significant progress has been made in cancer immunotherapies for specific cancers and patient populations. Research into the use of these therapies for other cancers and patients is ongoing.
  • Advances in radiotherapy include improved imaging and precision, proton beam therapy and molecular radiotherapy, all of which have also shown positive clinical results.
  • Combination therapies, which combine different types of immunotherapy, or drug and radiotherapies, are a priority for current and future research.
  • New therapies require specialised knowledge and resources; stakeholders agree that they should be delivered as part of a comprehensive multidisciplinary care package.

POSTnote Advances in Cancer Treatment