NIHR – November 2023
Surgeons use different procedures to remove abnormal cells in the cervix (the neck of the womb) and treat early cervical cancer. These treatments effectively reduce the risk that cancer will develop and spread, but they carry a risk of premature birth in future pregnancies. New research ranked the success and risks of different surgical treatments.
The review brought together studies including almost 89,000 women who had cell changes in the cervix (either pre- or early cancer).
Overall, the review found a trade-off between cancer prevention and the risk of problems in future pregnancies. Procedures that removed more cervical tissue reduced the risk of recurrence but increased the risk of a future premature birth.
The researchers recommend that a woman’s age, wishes for future childbearing, and the type and extent of abnormal cells, should drive the choice of treatment, after weighing up the risks and benefits of each.
This information will enable conversations between women and their surgeons about the approach that is best for them.
Further information – Prevention of cervical cancer: what are the risks and benefits of different treatments?
This Alert is based on Kyrgiou M, Athanasiou A, Cieslak-Jones D. Comparative effectiveness and risk of preterm birth of local treatments for cervical intraepithelial neoplasia and stage IA1 cervical cancer: a systematic review and network meta-analysis. Lancet Oncology 2022; 23: 1097–108.