NIHR| 4 February 2021| Active monitoring in early prostate cancer prevents as many deaths as surgery or radiotherapy, new research shows
New research indicates that ‘watch and wait’ also known as active monitoring in early prostate cancer prevents as many deaths as surgery or radiotherapy. The experts involved in this trial have observed that at 10-year median follow-up of patients with early prostate cancer, there was no difference in disease-specific mortality between active monitoring, radical prostatectomy and radical radiotherapy treatments, which caused different side-effect profiles.
It stuidied over 82 000 men between the ages of 50 and 69 who agreed to have a PSA test. Some 2664 were diagnosed with localised prostate cancer, and of this group, 1643 agreed to be randomly allocated to surgery, radiotherapy, or active monitoring. Urinary and sexual function was assessed by questionnaires completed by the men.
The results showed that in the ten years following their diagnosis:
- 99% of men were alive in each of the three groups
- compared with active monitoring, surgery and radiotherapy reduced the risk of disease spreading outside the prostate by half
- urinary leakage and sexual function were worst after surgery
- sexual and bowel functions were most affected by radiotherapy
- More than half (55%) men on active monitoring moved to a radical treatment but many (44%) remained disease free and avoided the side effects of treatments.
The study found that overall, quality of life was similar across all groups. Men on active monitoring had an expected gradual decline in their urinary and sexual function over time. The researchers concluded that longer follow-up is needed to determine the most cost-effective treatment for localised prostate cancer over a man’s lifetime.
This is a practice changer for the management of prostate cancer; many academics have called it the Greatest Trial Of all Time. After years of retrospective research with uncontrollable bias, it was the first large randomised controlled trial to compare surgery to radiotherapy and active monitoring for the treatment of localised prostate cancer. It showed no difference in survival in the different treatment groups which is essential news for counselling patients with a new diagnosis of prostate cancer.
Suneil Jain, Professor and Honorary Consultant in Clinical Oncology, Queen’s University of Belfast
(Source: NIHR)
The primary paper Active monitoring, radical prostatectomy and radical radiotherapy in PSA-detected clinically localised prostate cancer: the ProtecT three-arm RCT