Men dangerously unaware of family link to prostate cancer

Two-thirds of men with a family history of prostate cancer are dangerously unaware of their increased risk of the disease and half of all UK men don’t know that a family link makes you two-and-a-half times more likely to get it, according to new research by Prostate Cancer UK.

It’s prompted urgent calls from the charity for men and their families to have a potentially life-saving talk about the disease with their relatives and doctor. Especially since an accompanying study  showed that only 1-in-10 GPs are likely to always ask a man whether any close relatives have had the disease. Although where men did take the lead and initiate a discussion with their doctor, it found their experiences were overwhelmingly positive.

Drinking coffee may help prevent liver cancer, study suggests

People who drink more coffee are less likely to develop liver cancer, an analysis of data from 26 studies has found | Story via The Guardian | BMJ

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Researchers have found that people who drink more coffee are less likely to develop hepatocellular cancer (HCC), the most common form of primary liver cancer – and the effect was also found in decaffeinated coffee.

Experts from the University of Southampton and the University of Edinburgh examined data from 26 studies involving more than 2.25 million participants.  Compared with people who drank no coffee, those who drank one cup a day had a 20% lower risk of developing HCC, according to the study, published in the journal BMJ Open.

Those who consumed two cups a day had a 35% reduced risk and for those who drank five cups, the risk was halved. They found the protective effect for decaf was “smaller and less certain than for caffeinated coffee”

Full story via The Guardian

Full reference: Kennedy OJ, Roderick P, Buchanan R, et al. Coffee, including caffeinated and decaffeinated coffee, and the risk of hepatocellular carcinoma: a systematic review and dose–response meta-analysis

Where body fat is carried can predict cancer risk

Study finds men with over 40in waist and women with over 35in waist are more at risk of cancer as waist size is as good at predicting cancer risk as BMI | via Cancer Research UK 

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Scientists have found that carrying fat around your middle could be as good an indicator of cancer risk as body mass index (BMI), according to research published in the British Journal of Cancer . 

The study combined data from around 43,000 participants who had been followed for an average of 12 years and more than 1,600 people were diagnosed with an obesity-related cancer.

The study found that adding about 11cm to the waistline increased the risk of obesity related cancers by 13 per cent. For bowel cancer, adding around 8 cm to the hips is linked to an increased risk of 15 per cent.

Being overweight or obese is the single biggest preventable cause of cancer after smoking and is linked to 13 types of cancer including bowel, breast, and pancreas.

Full reference: Freisling et al. Comparison of general obesity and measures of body fat distribution in older adults in relation to cancer risk: meta-analysis of individual participant data of seven prospective cohorts in Europe. British Journal of Cancer. (2017) 116, 1486–1497

Read more at Cancer Research UK

Diet, nutrition, physical activity and breast cancer

The report analysed 119 studies and including data on 12 million women and 260,000 cases of breast cancer | World Cancer Research Fund

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Image source: WCRF

Many epidemiologic studies have classified breast cancer cases by menopausal status at time of diagnosis, and therefore in this report we chose to highlight associations between diet, weight, and physical activity separately in premenopausal and postmenopausal breast cancer, where possible.

Key findings: premenopausal breast cancer

There is strong evidence that:

  • consuming alcoholic drinks increases risk
  • undertaking vigorous physical activity decreases risk
  • being overweight or obese between the ages of about 18 and 30 years decreases risk
  • being overweight or obese in adulthood before the menopause decreases risk
  • developmental factors leading to greater linear growth (marked by adult attained height) increase risk
  • factors that lead to greater birthweight, or its consequences, increase risk
  • breastfeeding decreases risk (breast cancer type unspecified) in the mother
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Image Source: WCRF

Key findings: postmenopausal breast cancer

There is strong evidence that:

  • consuming alcoholic drinks increases risk
  • being physically active (including vigorous physical activity) decreases risk
  • being overweight or obese between the ages of about 18 and 30 years decreases risk
  • being overweight or obese throughout adulthood increases risk
  • greater weight gain in adulthood increases risk
  • developmental factors leading to greater linear growth (marked by adult attained height) increase risk
  • breastfeeding decreases risk (breast cancer type unspecified) in the mother
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Image source: WCRF

Sugar and cancer – what you need to know

There’s a lot of confusing information and advice out there around sugar. It’s been made the villain of our diet, but where does the consensus lie between how sugar and cancer are linked? | Cancer Research UK Science Blog

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Does it cause cancer? Does sugar feed cancer cells, making them grow more aggressively? And how does the sugar we consume through food and drink affect our health, and what can be done about this?

In this post we’re taking a long hard look at sugar.

We’ll focus specifically on sugar and cancer, busting some myths and covering what researchers are studying in the hopes of finding new ways to treat people with cancer.

And we’ll cover why the amount of sugar in our diets is cause for concern. A high-sugar diet can be bad news when it comes to cancer risk, but not for the reasons that often appear in the headlines.

But first the basics, what our bodies need sugar for and where it comes from in our diet.

Read the full blog post here

Coffee consumption linked to reduced risk of liver cancer

Kennedy, O.J. et al. (2017) Coffee, including caffeinated and decaffeinated coffee, and the risk of hepatocellular carcinoma: a systematic review and dose–response meta-analysis. BMJ Open. 7:e013739

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Objectives: To examine the association between coffee, including caffeinated and decaffeinated coffee, with hepatocellular carcinoma (HCC) and assess the influence of HCC aetiology and pre-existing liver disease.

Conclusions: Increased consumption of caffeinated coffee and, to a lesser extent, decaffeinated coffee are associated with reduced risk of HCC, including in pre-existing liver disease. These findings are important given the increasing incidence of HCC globally and its poor prognosis.

Read the full article here

Understanding GP attitudes to cancer preventing drugs

A study by Cancer Research UK concludes that GPs want more support when offering drugs that lower the risk of certain cancers. It finds that GPs are more comfortable to discuss drugs, and more willing to prescribe or recommend drugs when they are supported by secondary care clinicians. Cancer Research UK

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Understanding GP attitudes to cancer preventing drugs is aimed at increasing understanding GP attitudes towards offering the use of tamoxifen and aspirin to lower the risk of cancer, or prevent cancer. This is an area where there is little research around clinician attitudes and knowledge.

The study surveyed 1,007 GPs from across the UK. It found nearly half of GPs were unaware of the potential benefits of tamoxifen to prevent breast cancer among women with a clear family history of the disease who are therefore at higher risk.

The study also showed that more needs to be done to promote the evidence and guidance on chemoprevention. The research suggests that ensuring evidence based chemoprevention is routinely discussed with and offered to the people who may benefit should be a priority across the UK.

Executive summary: Understanding GP Attitudes to Cancer Preventing Drugs 

Full report: Understanding GP Attitudes to Cancer Preventing Drugs