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Welcome to the Cancer Services online newsfeed. Here you’ll find all the latest research, news stories, policy updates and guidelines. View our other newsfeeds for more subject-specific news.

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Cancer risk awareness and screening uptake in individuals at higher risk for colon cancer

Salimzadeh, H. et al. (2016) BMJ Open. 6:e013833

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Objective: We aimed to measure cancer knowledge and feasibility of a screening colonoscopy among a cohort of individuals at higher risk of colon cancer.

 

Conclusions: Our data indicated that remarkable numbers of FDRs were not still informed of their cancer risk or never received a physician recommendation for screening. The desirable uptake at first invitation, which would be higher over successive invitations, supports the feasibility of a family-based recruitment approach for early screening. This has promising implications to introduce targeted screening colonoscopy into the healthcare system in Iran and other developing nations.

Read the full article here

Transformation fund call to bid

To support the implementation of the Five Year Forward View vision of better health, better patient care and improved NHS efficiency, NHS England has created a transformation fund | NHS England

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The interventions for which transformation funding are available are:

Sustainability and Transformation Plans (STPs) are central to this process and all bids should be explicitly linked to the relevant local STP plans. This process is open to any STP, although individual organisations or alliances may bid on behalf of an STP for this funding; submission of applications must be via STPs.

Read the full overview here

Is upfront stereotactic radiosurgery a rational treatment option for very elderly patients with brain metastases?

Yomo, S & Hayashi, M. BMC Cancer. Published online: 15 December 2016

B0010355 Human brain cancer stem cells treated with graphene, SEM

Image source: Suffian, I. et al. – Wellcome Images // CC BY-NC-ND 4.0

 

Image shows false-coloured scanning electron micrograph of human cancer stem cells isolated from patients with brain cancer

Background: Advanced age has been shown to be a factor predicting poor survival in patients with brain metastases (BM). There have been only a few studies focusing on stereotactic radiosurgery (SRS) for elderly BM patients. The present study aimed to investigate the efficacy and limitations of SRS for very elderly BM patients.

Conclusions: The present study suggested an upfront SRS strategy to offer a feasible and effective treatment option for very elderly patients with limited BM. In the majority of patients, neurological death could be delayed or even prevented.

Read the full article here

NSAIDs and Endometrial Carcinoma Mortality and Recurrence

Brasky, T.M. et al. (2017) JNCI: Journal of National Cancer Institute. 109(3) djw251

B0010228 Diclofenac, anti-inflammatory and pain relief drug, LM

Image source: Maurice Mikkers – Wellcome Images // CC BY-NC-ND 4.0

Image shows cross polarised light micrograph of diclofenac.

Background: Recent data suggest that the use of nonsteroidal anti-inflammatory drugs (NSAIDs) may be associated with reductions in endometrial cancer risk, yet very few have examined whether their use is related to prognosis among endometrial cancer patients.

 

Conclusions: In this study, use of NSAIDs was associated with increased endometrial carcinoma–specific mortality, especially in patients with type I tumors. Barring a clear biologic mechanism by which NSAIDs would increase the risk of cause-specific mortality, cautious interpretation is warranted.

Read the full abstract here

 

Almost 20% of breast cancer patients fail to complete prescribed endocrine therapy

The study in over 5,500 women found that younger patients and those who had taken hormone replacement therapy (HRT) were less likely to  adhere to their medicine | ScienceDaily

Around 20% of breast cancer patients do not complete prescribed endocrine therapy, researchers report at the ESMO Asia 2016 Congress in Singapore.

The study included 5,544 women with ER positive breast cancer who collected at least one prescription of aromatase inhibitors or tamoxifen and had five years of follow up data. Women were identified and prescription information was obtained from the regional registers of Uppsala-Örebro, Stockholm-Gotland, and Northern Sweden which cover around 60% of the Swedish population. The data was linked to Swedish national registers with information about factors which could influence adherence. Adherence was calculated from the drugs dispensed — patients were classified as non-adherent if they received less than 80% of the drugs needed over five years.

During the five years, 20% of the women became non-adherent. In the multivariable analysis the strongest independent predictors of non-adherence were younger age, previous use of HRT, marital status, and socioeconomic status (measured by type of employment).

Read the full overview here

National Prostate Cancer Audit 2016 Annual Report

90% of men receiving curative treatment for prostate cancer say their care was very good

Prostate cancer is the most frequently diagnosed cancer in men and the third most common cause of cancer-related mortality in the United Kingdom, with about 40,000 new cases each year resulting in 10,000 deaths. The NPCA audit looks at whether NHS services in England and Wales for men diagnosed with prostate cancer meet recommended standards.

This is the third Annual Report from the National Prostate Cancer Audit (NPCA) and presents current data regarding prostate cancer care in England and in Wales. In this report, the NPCA gathered information directly from patients to find out their views of their experience of care and the functional impact of radical treatments on their lives.

The full report is available to download here

View press release here